Vascular Cell | Article collections | The Dll4/Notch pathway as a therapeutic target in tumors

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The Dll4/Notch pathway as a therapeutic target in tumors

Edited by: Prof Jan Kitajewski

This review series, developed by leaders in pharmaceutical and academic cancer research, presents an update on efforts to block tumor growth by targeting the Dll4/Notch pathway. This pathway is active during tumor angiogenesis and in cancer stem cells. The excitement about the effective targeting of tumors using this approach and the challenge of minimizing adverse responses are key points of discussion.

Collection published: 8 August 2011

Last updated: 9 April 2012

		Review Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy Jian-Wei Gu, Paola Rizzo, Antonio Pannuti, Todd Golde, Barbara Osborne, Lucio Miele Vascular Cell 2012, 4:7 (9 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Dll4-Notch signaling as a therapeutic target in tumor angiogenesis Frank Kuhnert, Jessica R Kirshner, Gavin Thurston Vascular Cell 2011, 3:20 (18 September 2011) Abstract \| Full text \| PDF \| PubMed
		Review Anti-DLL4, a cancer therapeutic with multiple mechanisms of action Austin Gurney, Timothy Hoey Vascular Cell 2011, 3:18 (10 August 2011) Abstract \| Full text \| PDF \| PubMed
		Review Therapeutic promise and challenges of targeting DLL4/NOTCH1 Minhong Yan Vascular Cell 2011, 3:17 (8 August 2011) Abstract \| Full text \| PDF \| PubMed

		Review Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy Jian-Wei Gu, Paola Rizzo, Antonio Pannuti, Todd Golde, Barbara Osborne, Lucio Miele Vascular Cell 2012, 4:7 (9 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Dll4-Notch signaling as a therapeutic target in tumor angiogenesis Frank Kuhnert, Jessica R Kirshner, Gavin Thurston Vascular Cell 2011, 3:20 (18 September 2011) Abstract \| Full text \| PDF \| PubMed
		Review Anti-DLL4, a cancer therapeutic with multiple mechanisms of action Austin Gurney, Timothy Hoey Vascular Cell 2011, 3:18 (10 August 2011) Abstract \| Full text \| PDF \| PubMed
		Review Therapeutic promise and challenges of targeting DLL4/NOTCH1 Minhong Yan Vascular Cell 2011, 3:17 (8 August 2011) Abstract \| Full text \| PDF \| PubMed