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Open Access Research

Vascular endothelial growth factor-B expression in postischemic rat brain

Lin Xie1, Xiaoou Mao1, Kunlin Jin12 and David A Greenberg1*

Author Affiliations

1 Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA

2 Department of Pharmacology & Neuroscience, University of North Texas, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA

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Vascular Cell 2013, 5:8  doi:10.1186/2045-824X-5-8

Published: 20 April 2013

Abstract

Background

Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain.

Methods

We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1–7 days after middle cerebral artery occlusion in rats.

Results

VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells.

Conclusions

These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.

Keywords:
Vascular endothelial growth factor-B (VEGF-B); Stroke; Ischemia