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Open Access Highly Accessed Review

Myeloid cells in tumor inflammation

Michael C Schmid and Judith A Varner*

Author Affiliations

Moores UCSD Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, La Jolla, CA, 92093-0912, USA

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Vascular Cell 2012, 4:14  doi:10.1186/2045-824X-4-14

Published: 3 September 2012

Abstract

Bone marrow derived myeloid cells progressively accumulate in tumors, where they establish an inflammatory microenvironment that is favorable for tumor growth and spread. These cells are comprised primarily of monocytic and granulocytic myeloid derived suppressor cells (MDSCs) or tumor-associated macrophages (TAMs), which are generally associated with a poor clinical outcome. MDSCs and TAMs promote tumor progression by stimulating immunosuppression, neovascularization, metastasis and resistance to anti-cancer therapy. Strategies to target the tumor-promoting functions of myeloid cells could provide substantial therapeutic benefit to cancer patients.

Keywords:
Macrophage; Myeloid derived suppressor cells; Tumor angiogenesis; Tumor microenvironment; Tumor inflammation; Cancer