Email updates

Keep up to date with the latest news and content from Vascular Cell and BioMed Central.

Open Access Highly Accessed Review

Macrophages and angiogenesis: a role for Wnt signaling

Andrew C Newman1 and Christopher C W Hughes123*

Author Affiliations

1 The Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA

2 The Department of Biomedical Engineering, University of California Irvine, Irvine, CA, 92697, USA

3 The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California Irvine, Irvine, CA, 92697, USA

For all author emails, please log on.

Vascular Cell 2012, 4:13  doi:10.1186/2045-824X-4-13

Published: 31 August 2012

Abstract

Macrophages regulate many developmental and pathological processes in both embryonic and adult tissues, and recent studies have shown a significant role in angiogenesis. Similarly, Wnt signaling is fundamental to tissue morphogenesis and also has a role in vascular development. In this review, we summarize recent advances in the field of macrophage-regulated angiogenesis, with a focus on the role of macrophage-derived Wnt ligands. We review data that provide both direct and indirect evidence for macrophage-derived Wnt regulation of physiologic and pathologic angiogenesis. Finally, we propose that Wnt signaling plays a central role in differentiation of tumor associated and wound infiltrating macrophages to a proangiogenic phenotype.

Keywords:
Macrophage; Angiogenesis; Wnt