Table 1 |
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Comparison Wnt-mediated regulation of the EAhy926 immortalized cell line and HUVECs. |
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Human endothelial immortalized cell line EAhy926, treated with Wnt3a (our results) |
Primary HUVECs, treated with Wnt3a [17] |
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Increase of nuclear β-catenin |
Stabilization of total cellular β-catenin |
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Activation of Wnt/β-catenin throughput |
Induction of DVL3 phosphorylation |
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Up-regulation of full length Lef1 |
Data are not available |
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Increase in proliferation (MTT) after Lef1 transfection |
Increase in proliferation (BrdU incorporation) |
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Elevation of MMP2 |
No change in MMP-1 |
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Lef1 siRNA induced inhibition of MMP2 response |
Data are not available |
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Increase of invasion |
Increase of migration |
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Data are not available |
No effect on survival |
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Planutiene et al. Vascular Cell 2011 3:28 doi:10.1186/2045-824X-3-28 |
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