Table 4 |
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|
Randomized clinical studies on transplantation of cells which include endothelial progenitors |
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|
Study/year |
Disorder |
N |
Delivery route |
Cells delivered |
Follow-up (months) |
Effectiveness |
|
|
||||||
|
Strauer et al. (2002) [117] |
AMI |
20 |
Intracoronary |
BM-MNCs |
4 |
Effective |
|
Kang et al. MAGIC (2004) [92] |
AMI Old MI |
27 |
Intracoronary |
PB-MNCs and G-CSF |
6 |
Effective, but high rate of in-stent re-stenosis |
|
Schachinger et al. TOPCARE-AMI (2004) [118] |
AMI |
59 |
Intracoronary |
PB-MNCs or BM-MNCs |
12 |
Effective |
|
Ruan et al. (2005) [119] |
Acute MI |
20 |
Intracoronary |
BM-MNCs |
6 |
Effective |
|
Strauer et al. IACT (2005) [120] |
Chronic CAD |
36 |
Intracoronary |
BM-MNCs |
3 |
Effective |
|
Bartunek et al. (2005) [111] |
Recent MI |
35 |
Intracoronary |
CD133+ |
4 |
Effective |
|
Erbs et al. (2005) [112] |
Chronic CAD |
26 |
Intracoronary |
Cultured PB-EPCs |
3 |
Effective |
|
Assmus et al. (2006) [111] |
Chronic CAD |
53 |
Intracoronary |
BM-MNCs |
3 |
Effective |
|
Meyer et al. BOOST (2006) [104] |
Acute MI |
60 |
Intracoronary |
BM-MNCs |
18 |
Effective at 6 month, ineffective at 18 month |
|
Hendrikx et al. (2006) [121] |
Heart failure |
20 |
Intramyocardial |
BM-MNCs |
4 |
Ineffective |
|
Janssens et al. (2006) [105] |
MI |
67 |
Intracoronary |
BM-MNCs |
4 |
Ineffective |
|
Kang et al. MAGIC Cell-3-DES (2006) [60] |
Acute MI Old MI |
82 |
Intracoronary |
PB-MNCs and G-CSF |
6 |
Effective |
|
AMI |
201 |
Intracoronary |
BM-MNCs |
12 |
Effective |
|
|
Ge et al. TCT-STAMI (2006) [95] |
MI |
20 |
Intracoronary |
BM-MNCs |
6 |
Effective |
|
Meluzin et al. (2007) [122] |
Acute MI |
60 |
Intracoronary |
BM-MNCs |
12 |
Effective |
|
|
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|
AMI - acute myocardial infarction, BM - bone marrow, CAD - coronary artery disease, G-CSF - granulocyte-colony stimulating factor, MI - myocardial infarction, MNC - mononuclear cell, PB - peripheral blood. |
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|
Siddique et al. Journal of Angiogenesis Research 2010 2:6 doi:10.1186/2040-2384-2-6 |
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