Research
Methylnaltrexone Potentiates the Anti-Angiogenic Effects of mTOR Inhibitors
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* Corresponding author: Patrick A Singleton psinglet@medicine.bsd.uchicago.edu
1 Department of Medicine, University of Chicago, 5841 S. Maryland Avenue, W604, Chicago, IL, 60637, USA
2 Department of Anesthesia and Critical Care, University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL, 60637, USA
Journal of Angiogenesis Research 2010, 2:5 doi:10.1186/2040-2384-2-5
Published: 19 February 2010Additional files
Additional file 1:
Determination of methylnaltrexone (MNTX) synergistic effects with rapamycin on inhibition of VEGF-induced human endothelial cell (EC) proliferation and migration. This file shows through inhibition curves and isobologram analysis that MNTX acts synergistically with the mTOR inhibitor, rapamycin, on inhibition of VEGF-induced angiogenic events.
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